Targeted protein degradation via cellular trafficking of nanoparticles.

• Tác giả: Jiawei Dong, Linlin Fan, Mengke Fang, Kam W Leong, Runhan Liu, Yang Liu, Bingyang Shi, Sijun Wei, Xue Xia, Haoying Yang, Meng Zheng, Yan Zou
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature nanotechnology , 2025
• Bộ sưu tập: NCBI
• ID: 188118

Tóm tắt

Strategies that selectively bind proteins of interest and target them to the intracellular protein recycling machinery for targeted protein degradation have recently emerged as powerful tools for undruggable targets in biomedical research and the pharmaceutical industry. However, targeting any new protein of interest with current degradation tools requires a laborious case-by-case design for different diseases and cell types, especially for extracellular targets. Here we observe that nanoparticles can mediate specific receptor-independent internalization of a bound protein and further develop a general strategy for degradation of extracellular proteins of interest by making full use of clinically approved components. This extremely flexible strategy aids in targeted protein degradation tool development and provides knowledge for targeted drug therapies and nanomedicine design.