Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis.

• Tác giả: Corrado Barbui, Kristina M Deligiannidis, Chiara Gastaldon, Lauren M Osborne, Jennifer L Payne, Georgios Schoretsanitis, Inger Sundström-Poromaa, Elizabeth S Wenzel
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: England : Molecular psychiatry , 2025
• Bộ sưu tập: NCBI
• ID: 188204

Tóm tắt

Neuroactive steroids including allopregnanolone are implicated in the pathophysiology of peripartum depressive symptoms (PDS). We performed a systematic review searching PubMed/Embase/PsychInfo/Cinhail through 08/2023 (updated in 07/2024), and conducted a random-effects meta-analysis of studies comparing allopregnanolone blood concentrations in women with versus without PDS at various timepoints during the 2