PURPOSE: Radiolabeled probes targeting prostate-specific membrane antigen (PSMA) have been used in prostate cancer. Moreover, PSMA is also overexpressed on neovessels in hepatocellular carcinoma (HCC). This study aimed to preliminarily evaluate the diagnostic effectiveness of [ METHODS: Patients suspected of HCC were prospectively enrolled in this single-center study (NCT05006326, 2021-08-16) to perform [ RESULTS: A total of 12 patients (ten men and two women
mean age 58.75 ± 12.08 years) were included. Ten patients were diagnosed with HCC, 2 with intrahepatic cholangiocarcinoma (ICC), and 4 with hemangioma. The SUVmax, TLR, TBR, and TPR of HCC primary tumors were higher than those of ICC and hemangioma. The diagnostic accuracy of [ CONCLUSION: Utilizing a hybrid PET/MRI system to combine [ TRIAL REGISTRATION: NCT05006326. Registered August 16, 2021, https://clinicaltrials.gov/study/NCT05006326 .