Presynaptic terminal integrity is associated with glucose metabolism in Parkinson's disease.

• Tác giả: Yihui Guan, Yuqing Hu, Fengchun Hua, Qi Huang, Yiyun Huang, Junpeng Li, Yuxin Li, Xueling Liu, Shuhua Ren, Weiyi Wang, Yanru Wang, Fang Xie, Limin Xu, Qing Ye
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: Germany : European journal of nuclear medicine and molecular imaging , 2025
• Bộ sưu tập: NCBI
• ID: 188320

Tóm tắt

 OBJECTIVE: To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients. METHODS: A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [ RESULTS: Compared with that in the NC group, the synaptic density in the caudate region was significantly lower in the PD group (SUVR: 2.51 ± 0.36 vs. 3.18 ± 0.32, p <
  0.001), especially in the pre-commissural caudate and post-commissural caudate (SUVR: 2.42 ± 0.29 vs. 2.63 ± 0.32, p <
  0.01
  0.76 ± 0.31 vs. 0.97 ± 0.33, p <
  0.001). A reduced synaptic density was significantly correlated with DAT (r = 0.61, p <
  0.001) and glucose metabolism (r = 0.73, p <
  0.001) in the post-commissural caudate. In the post-commissural regions of the caudate, there was a partial mediating effect of synaptic density on the relationship between glucose metabolism and DAT availability (indirect effect: β CONCLUSION: [