High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics.

• Tác giả: Marc O Anderson, Joseph Anthony-Tan, Tifany Chu, Onur Cil, Peter M Haggie, Joy Karmakar, Riya J Master, Alan S Verkman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.453 Tin
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 188714

Tóm tắt

Pendrin (SLC26A4) is an anion exchanger expressed in epithelial cells of kidney and lung. Pendrin inhibition is a potential treatment approach for edema, hypertension and inflammatory lung diseases. We have previously identified first-in-class pendrin inhibitors by high-throughput screening, albeit with low potency for pendrin inhibition (IC