A novel murine syngeneic CD8 peripheral T-cell lymphoma model with preclinical applications.

• Tác giả: Joseph Lownik, Akil Merchant, Larry Milshteyn, Anton Villamejor
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Leukemia & lymphoma , 2025
• Bộ sưu tập: NCBI
• ID: 188747

Tóm tắt

Peripheral T-cell Lymphoma (PTCL) represents a heterogenous group of aggressive non-Hodgkin Lymphomas with poor prognostic outcomes and limited treatment options. The development and refinement of therapeutic strategies for PTCL are impeded by a paucity of reliable preclinical models that accurately mimic the disease's pathophysiology. There is a dire need for more physiologically relevant models for PTCL. Here we describe a spontaneousCD8