Circulating monocyte adhesion repairs endothelium-denuded injury through downstream of kinase 3-mediated endothelialization.

• Tác giả: Wen-Wu Bai, Lin Chen, Tao Guo, Zhi-Peng Song, Qian-Wen Wang, Shuang-Xi Wang, Jia-Yao Xu, Zhen-Shan Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Biochimica et biophysica acta. Molecular basis of disease , 2025
• Bộ sưu tập: NCBI
• ID: 188981

Tóm tắt

The integrity of the endothelial monolayer is critical for preventing life-threatening hemorrhaging and thrombosis. However, how severe endothelium-denuded injury is rapidly repaired remains unknown. Given the common biological properties between endothelial cells and circulating monocytes, we aimed to examine whether blood monocytes are involved in endothelium wound healing. The in vivo common carotid artery endothelium-denuded (CCAED) model was established through a wire-induced injury. Monocyte adhesion was assessed using immunofluorescence and a parallel plate flow chamber. We initially observed that the circulating monocyte-mediated endothelialization was better downstream of kinase 3 deficient mice (DOK3