PURPOSE: To investigate the predictive value of 2-[18F]-fluoro-2-deoxy-D-glucose ([ METHODS: In the single-arm phase 1b NATION-1907 trial (NCT04215471), 23 patients with LA-ESCC received two cycles of neoadjuvant PD-L1 blockade Adebrelimab followed by surgery. Among these, 18 patients underwent [ RESULTS: In the PT analysis, 10 patients were classified as PT well-responders and 8 as PT poor-responders. All post-treatment metabolic parameters, except MTV, were significantly lower in well-responders compared to poor-responders. The %ΔMTV, %ΔTLG were significantly higher in the poor-responder group (all P <
0.05). ROC curves indicated %ΔMTV CONCLUSION: The metabolic parameters of [