Assessment of fully quantitative and simplified methods for analysis of [

• Tác giả: Ronald Boellaard, Matthijs C F Cysouw, Lioe-Fee de Geus-Oei, Marijke den Hollander, Harry Hendrikse, Rutger B Henrar, Geert Kazemier, Daniela E Oprea-Lager, Xavier Palard-Novello, Patrick Schober, Robert C Schuit, Rutger-Jan Swijnenburg, Alexander L Vahrmeijer, Albert D Windhorst, Maqsood Yaqub
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : European journal of nuclear medicine and molecular imaging , 2025
• Bộ sưu tập: NCBI
• ID: 189462

Tóm tắt

PURPOSE: The aim of this study was to validate simplified methods for quantifying [ METHODS: Ten patients with pancreatobiliary cancer underwent a 90-min dynamic PET/CT scan using a long axial field of view system. Arterial blood samples were used to establish calibrated plasma-input function from both continuous arterial sampling and image-derived input function (IDIF). Lesional [ RESULTS: One patient was excluded due to discontinued scan acquisition and missing arterial sampling. Thirteen tumoral lesions and 11 non-tumoral lesions were included. A reversible 2-tissue-compartment model showed most preferrable fits for all types of [ CONCLUSION: Image-based TBR and SUVmean at 60-70 min p.i are suitable for quantifying [ TRIAL REGISTRATION: EudraCT, EudraCT 2022-001867-29. Registered 02 November 2022.