Assembly and performance of a cholera RDT prototype that detects both

• Tác giả: Noor Jahan Akter, Romana Akter, Yasmin Ara Begum, Piyash Bhattacharjee, Taufiqur Rahman Bhuiyan, Md Shawkat Hossain, Mahbubul Karim, Karen L Kelley, Ashraful Islam Khan, Imrul Kayes Nabil, Eric J Nelson, Firdausi Qadri, Md Abu Sayeed
• Ngôn ngữ: eng
• Ký hiệu phân loại: 323.47 Rights of assembly and association
• Thông tin xuất bản: United States : Journal of clinical microbiology , 2025
• Bộ sưu tập: NCBI
• ID: 189504

Tóm tắt

Cholera rapid diagnostic tests (RDTs) are vulnerable to virulent bacteriophage predation. We hypothesized that an enhanced cholera RDT that detects the common virulent bacteriophage ICP1 might serve as a proxy for pathogen detection. We previously developed a monoclonal antibody (mAb) to the ICP1 major capsid protein. Our objective was to design and assemble a first-of-its-kind RDT that detects both a bacterial pathogen (