Where Are All the Clinical Trials for Chronic Rejection?

• Tác giả: Paolo Cravedi, Josh Levitsky, Umberto Maggiore, Paolo Molinari, Emmanuel Zorn
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Transplantation , 2025
• Bộ sưu tập: NCBI
• ID: 189590

Tóm tắt

Chronic rejection is arguably the main obstacle to long-term graft survival. Yet, clinical trials focusing on this condition are disappointingly scarce. Significant advances in treating chronic rejection cannot happen if there is no conduit for testing novel therapies. Here, we identified the main hurdles holding back clinical trials for chronic rejection and outlined a series of actions to address these roadblocks. We suggest that a new strategic plan combining expertise in basic and clinical research and leveraging complementary resources be launched to specifically target chronic rejection and achieve long-awaited progress. We only need the will.