Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir.

• Tác giả: Jana Blazkova, Zabrina L Brumme, Clarisa M Buckner, Tae-Wook Chun, Aaron S Devanathan, Winnie Dong, Kathleen Gittens, Jeanette Higgins, Jesse S Justement, Lela Kardava, Brooke D Kennedy, Kathryn Lurain, Ralph Mangusan, Maegan R Manning, Susan Moir, Alice K Pau, M Ali Rai, Ramya Ramaswami, Adeline B Sewack, Aniqa Shahid, Victoria Shi, Michael C Sneller, Raymond E West, Robert Yarchoan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 297.1248 Sources of Islam
• Thông tin xuất bản: United States : Nature medicine , 2025
• Bộ sưu tập: NCBI
• ID: 189667

Tóm tắt

The clinical management of people with multidrug-resistant (MDR) human immunodeficiency virus (HIV) remains challenging despite continued development of antiretroviral agents. A 58-year-old male individual with MDR HIV and Kaposi sarcoma (KS) was treated with a new antiretroviral regimen consisting of anti-CD4 domain 1 antibody UB-421 and capsid inhibitor lenacapavir. The individual experienced delayed but sustained suppression of plasma viremia and a substantial increase in the CD4