Hexachlorobutadiene (HCBD), as an emerging persistent organic pollutant, poses a pressing global environmental issue concerning its reduction and control. However, the lack of systematic studies on the sources and occurrence of HCBD hinders the development of effective disposal technologies. This study addresses HCBD prevention and treatment from multiple perspectives, including source emissions, environmental contamination distribution, and control technologies. The dominant source of HCBD emissions varied by country, mainly industrial production processes of trichloroethylene, perchloroethylene, and carbon tetrachloride in China and magnesium production in Europe. Further research on the relevant generation mechanisms is necessary to develop targeted source control strategies. HCBD has been detected in various environmental media and biological organisms worldwide. Compared to sludge and soil, the concentration of HCBD in the atmosphere and water were relatively higher, particularly in China and Nigeria, with the concentration reaching up to 179 μg/m