Computational insights into the aggregation mechanism of human calcitonin.

• Tác giả: Feng Ding, Xinjie Fan, Fengjuan Huang, Jiangfang Lian, Zhongyue Lv, Yunxiang Sun, Huan Xu, Yu Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 261.836 Population
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 190003

Tóm tắt

Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT