Myocardial Fibroblast Activation After Acute Myocardial Infarction: A Positron Emission Tomography and Magnetic Resonance Study.

• Tác giả: Andrew H Baker, Anna K Barton, Bronwyn Berkeley, Daniel Berman, Mairi Brittan, Tim Clark, Neil J Craig, Damini Dey, Marc R Dweck, Alison Fletcher, Shruti Joshi, Joel Lenell, Krithika Loganath, Mark G MacAskill, Menaka Mahendran, Jennifer Nash, David E Newby, Stephanie Sellers, Trisha Singh, Riemer H J A Slart, Piotr Slomka, Vasiliki Tsampasian, Evangelos Tzolos, Edwin J R van Beek, Stefan Vezaides, Clint Waight, Beth Whittington, Michelle C Williams
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of the American College of Cardiology , 2025
• Bộ sưu tập: NCBI
• ID: 190046

Tóm tắt

 BACKGROUND: Myocardial fibrosis is a key healing response after myocardial infarction driven by activated fibroblasts. Gallium-68-labeled fibroblast activation protein inhibitor ([ OBJECTIVES: The aim of this study was to investigate the intensity, distribution, and time-course of fibroblast activation after acute myocardial infarction. METHODS: A total of 40 patients with acute myocardial infarction underwent hybrid [ RESULTS: Myocardial [ CONCLUSIONS: Myocardial fibroblast activation peaks within a week of acute myocardial infarction and extends beyond the infarct region. It declines slowly with time, persists for years, and is associated with subsequent left ventricular remodeling. (PROFILE-MI-The FAPI Fibrosis Study
  NCT05356923).