Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway.

• Tác giả: A K N Daltveit, E M Dennison, N C Harvey, M Hoff, Hilde Thomasli Holltrø, K Holvik, J Horn, A Langhammer, T I L Nilsen, B Schei, I Tronstad
• Ngôn ngữ: eng
• Ký hiệu phân loại: 286.136 *American Baptist Association
• Thông tin xuất bản: England : Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA , 2025
• Bộ sưu tập: NCBI
• ID: 190102

Tóm tắt

 UNLABELLED: This population study investigated the association between birth characteristics and fracture risk in 11,099 young adults (aged 19-54 years). Our findings indicate that birth weight, gestational age, and birth weight for gestational age were not associated with fractures in the wrist, humerus, hip, and spine in this population. PURPOSE: Skeletal development starts during fetal life, and it is estimated that most bone formation occurs in the 3rd trimester. This study examined the association between birth characteristics and fractures of the wrist, humerus, hip, and spine, in young adults (19-54 years). METHODS: 11.099 participants in the 3 RESULTS: During a median follow-up of 14.0 years (153,657 person-years), 290 fractures occurred. Mean age at first fracture was 41.4 years (SD 7.4). Overall, there were no clear associations between birth characteristics and fractures in these data. HR for fracture was 0.43 (0.15-1.24) for those with a birth weight <
  2.5 kg (reference birth weight 3.5 - 3.9 kg)
  1.04 (0.74 - 1.46) for those born small for gestational age (<
  10th percentile, reference 10 - 90 CONCLUSION: Birth weight, gestational age, or birth weight for gestational age was not associated with an increased risk of fractures of the wrist, humerus, hip, and spine in young adults.