OBJECTIVE: This study aimed to explore the prospective associations of organizational changes with health outcomes among employees who remained in employment. METHODS: The study relied on the prospective data of the national French working conditions survey collected from employees and their employers in 2013, 2016, and 2019. The study sample included 4480 private sector employees. Organizational changes were assessed by the employers. The two health outcomes, collected from the employees, were psychological well-being and self-reported health. The prospective associations between organizational changes and health outcomes were studied using multilevel mixed-effects linear and robust Poisson regression models. RESULTS: No association was found between organizational changes and well-being and self-reported health. CONCLUSIONS: Our study did not find significant prospective associations between organizational changes and two health outcomes among employees who remained in employment. More high-quality research is needed.