Diastereoselective β-hydroxy vinylsulfone isomerizations.

• Tác giả: D M Carnahan, T D Clark, H Crockett, A P Jones, G W O'Neil, C Wallace
• Ngôn ngữ: eng
• Ký hiệu phân loại: 331.7 Labor by industry and occupation
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 190421

Tóm tắt

 Vinylic phenylsulfones containing a β-hydroxyl stereocenter undergo a diastereoselective isomerization to the corresponding allylic isomer upon treatment with 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU). Diastereoselectivity of this reaction increases with increasing size of the group attached to the carbinol carbon (up to >
 20 : 1 dr with a