Zinc nanoparticles from oral supplements accumulate in renal tumours and stimulate antitumour immune responses.

• Tác giả: Xichen Chen, Bozhao Li, Guorong Li, Suping Li, Zefang Lu, Qiaoli Lv, Guangjun Nie, Qing Wang, Ting Wang, Zhenzhu Wang, Zongping Wang, Aiwen Wu, Fengrui Wu, Yiqi Wu, Xin Xia, Xin Zeng, Gen Zhang, An Zhao, Wene Zhao, Yuliang Zhao, Zhixiang Zuo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 306.877 Incest
• Thông tin xuất bản: England : Nature materials , 2025
• Bộ sưu tập: NCBI
• ID: 190454

Tóm tắt

A successful therapeutic outcome in the treatment of solid tumours requires efficient intratumoural drug accumulation and retention. Here we demonstrate that zinc gluconate in oral supplements assembles with plasma proteins to form ZnO nanoparticles that selectively accumulate into papillary Caki-2 renal tumours and promote the recruitment of dendritic cells and cytotoxic CD8