Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban children.

• Tác giả: Matthew C Altman, Leonard B Bacharier, Patrice M Becker, William W Busse, Courtney L Gaberino, James E Gern, Michelle A Gill, Rebecca S Gruchalla, Daniel J Jackson, Meyer Kattan, Gurjit K Khurana Hershey, Rajesh Kumar, Andrew H Liu, George T O'Connor, Stephen J Teach, Alkis Togias, Cynthia Visness, Edward M Zoratti
• Ngôn ngữ: eng
• Ký hiệu phân loại: 261.836 Population
• Thông tin xuất bản: United States : The Journal of allergy and clinical immunology , 2025
• Bộ sưu tập: NCBI
• ID: 190630

Tóm tắt

BACKGROUND: Determining why some upper respiratory illnesses provoke asthma exacerbations remains an unmet need. OBJECTIVE: We sought to identify transcriptome-wide gene expression changes associated with colds that progress to exacerbation. METHODS: Two hundred eight urban children (6-17 years) with exacerbation-prone asthma were prospectively monitored for up to 2 cold illnesses. Exacerbation illnesses (Ex RESULTS: One hundred six participants were evaluated during 154 colds. There was greater upregulation of differentially expressed interferon genes during Ex CONCLUSION: Dysregulated interferon responses are important contributors to asthma exacerbation risk in children. Low baseline interferon expression followed by greater upregulation of interferon pathways in airway and blood during respiratory illnesses increased exacerbation risk. Targeting this pathway in at-risk individuals holds promise for the personalized prevention of asthma exacerbations.