Fabrication of Rubus chingii Hu ellagitannins-loaded W/O and O/W emulsion gels: Structure, stability, in vitro digestion and in vivo metabolism.

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Tác giả: Ming-Shun Chen, Dong-Jun Hou, Xiao-Yan Jia, Dai-Wei Ke, Zong-Cai Tu, Quan-Yuan Xie, Lu Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 190699

Tannin is the main naturally occurring phytochemicals in Rubus chingii Hu with poor digestive stability and low bioavailability. In this study, oil-in-water (O/W) and water-in-oil (W/O) emulsion gels encapsulating Rubus chingii Hu ellagitannins (RCHT) were fabricated and their structure, rheology, stability, in vitro digestion and in vivo metabolism were characterized. The W/O emulsion gel showed smaller particle size, better pH stability, thermal stability, centrifugal stability and storage stability. Regarding rheology, two emulsion gels exhibited characteristics of non-Newtonian fluids. The encapsulation efficiency of W/O emulsion gel was higher, reaching 95.46 %. The lower release rate and higher bioaccessibility of RCHT were also observed in the W/O emulsion gel. In vitro fermentation results indicated that W/O emulsion gel could promote the growth of intestinal beneficial bacteria and inhibit the growth of harmful bacteria. Metabolic kinetics in rats showed that the embedding of W/O emulsion gel greatly promoted the absorption and transformation of ellagitannins to urolithins in vivo. Thus, the W/O emulsion gel was quite suitable for the delivery of RCHT.
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