Traditional wound dressings, primarily centered on antimicrobial or bactericidal strategies, have inadvertently contributed to the rise of drug-resistant bacterial colonies at wound sites, thus prolonging the healing process. In this study, we developed an innovative hydrogel dressing, CMCS-PVA@CA, incorporating carboxymethyl chitosan (CMCS), polyvinyl alcohol (PVA), and cichoric acid (CA), specifically designed to treat skin wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Computational biology analyses reveal that CA exerts substantial anti-virulence activity by targeting serine/threonine phosphatase (Stp1), achieving an IC