Transport and action of sesame protein-derived ACE inhibitory peptides ITAPHW and IRPNGL.

• Tác giả: Tonghao Du, Tao Huang, Xizhuo Huang, Huiyu Li, Jiahui Li, Yuan Qin, Mingyong Xie, Shijin Xiong, Tao Xiong, Xiaoyan Xu, Jiahui Yang, Linli Zhang, Mingwei Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Food chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 190825

Tóm tắt

Vascular endothelial dysfunction is an important pathogenic factor in hypertension, in which angiotensin-converting enzyme (ACE) plays an important role. Peptides that bind to ACE may attenuate vascular endothelial dysfunction by altering the structure of ACE. This study demonstrated that ITAPHW and IRPNGL were resistant to simulated gastrointestinal fluid and were transported across the Caco-2 monolayer via the intercellular space, with ITAPHW showing a high apparent permeability coefficient of (1.44 ± 0.01) × 10