D-glucose-conjugated thioureas containing 2-aminopyrimidine as potential multitarget inhibitors for type 2 diabetes mellitus: Synthesis and biological activity study.

• Tác giả: Nguyen Dinh Thanh, Vu Ngoc Toan, Vu Minh Trang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.462 Diabetes mellitus
• Thông tin xuất bản: United States : Computers in biology and medicine , 2025
• Bộ sưu tập: NCBI
• ID: 191013

Tóm tắt

α-d-Glucose-conjugated thioureas 8a-w of substituted 4,6-diaryl-2-aminopyrimindines were designed, synthesized, and screened for their antidiabetic inhibitory activity. The thioureas with the strongest potential inhibitory activity included 8f (IC