Significant losses of vegetables and fruits occur at multiple stages, including harvest, sorting, storage, and transportation, primarily due to mechanical damage, pathogen invasion, and the natural process of senescence. To mitigate postharvest decay and maintain superior quality of produce, conventional techniques such as low temperature storage and synthetic fungicide treatment are widely employed. Acibenzolar-S-methyl (ASM), an effective plant resistance inducers, has demonstrated its efficacy in protecting against a diverse range of fungal and bacterial pathogens. The present review primarily concludes that exogenous application of ASM effectively maintains postharvest quality, delays senescence, and controls decay of postharvest fruits and vegetables through the following mechanisms: (1) modulation of signal transduction pathways including Ca