Nanoparticles modified with glucose analogs to enhance the permeability of the blood-brain barrier and their accumulation in the epileptic brain.

• Tác giả: Yuwen Chen, Lijie Feng, Dengyuan Hao, Jianxiang Lei, Jinshuai Liu, Fengqing Lu, Qian Meng, Yu Wang, Hao Yang, Zifan Yang, Xiaoyu Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.0835 Other branches of medicine Gynecology and obstetrics
• Thông tin xuất bản: England : Journal of materials chemistry. B , 2025
• Bộ sưu tập: NCBI
• ID: 191113

Tóm tắt

Drug delivery for epilepsy treatment faces enormous challenges, where the sole focus on enhancing the ability of drugs to penetrate the blood-brain barrier (BBB) through ligand modification is insufficient because of the absence of seizure-specific drug accumulation. In this study, an amphipathic drug carrier with a glucose transporter (GLUT)-targeting capability was synthesised by conjugating 2-deoxy-2-amino-D-glucose (2-DG) to the model carrier DSPE-PEG