Ligand-restricted synNotch switches enable precision cell therapy.

• Tác giả: Dan Hu, Xuyang Li
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Trends in immunology , 2025
• Bộ sưu tập: NCBI
• ID: 191151

Tóm tắt

Lim and colleagues demonstrate that synNotch transcriptional circuits engineered into T cells can be used to precisely control location-specific expression of payloads responding to antigen triggers, thus locally inhibiting unwanted immunity or neuroinflammation. With no off-tumor toxicity or systemic immunosuppression upon elimination of mouse brain tumors, this approach can achieve better efficacy than anticipated.