Ag(I)-promoted fragment coupling of peptide thioamides.

• Tác giả: Carlie L Charron, Craig A Hutton, Varsha J Thombare
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.0835 Other branches of medicine Gynecology and obstetrics
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 191214

Tóm tắt

Despite advances in solid phase peptide synthesis and peptide ligation, challenges remain in the assembly of polypeptides through coupling of peptide fragments. Herein we describe a new method for peptide fragment coupling employing the Ag(I)-promoted transformation of peptide thioamides. This process proceeds