Cellular RNA acts as an antiviral MAVS signalosome scaffold.

• Tác giả: Xuetao Cao, Yang Liu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 353.999 *Radioactive products
• Thông tin xuất bản: England : Trends in immunology , 2025
• Bộ sưu tập: NCBI
• ID: 191331

Tóm tắt

The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.