Currently, the development of novel pesticides remains a crucial initiative to address the challenges of agricultural pest management. In pursuit of agrochemical candidates derived from plant natural products (NPs), 76 novel isoxazoline-hybridized honokiol/magnolol analogues were assembled via a [3 + 2] dipolar cycloaddition reaction, and their pesticidal potency and cytotoxicity were evaluated. Bioassays revealed that 13 compounds (