HINT1 Inhibitors as Selective Modulators of MOR-NMDAR Cross-Regulation and Non-Opioid Analgesia.

• Tác giả: Maxwell Dillenburg, Rafal Dolot, Carolyn A Fairbanks, Kelley F Kitto, Kostana Ligori, Cristina D Peterson, Carston R Wagner, George L Wilcox
• Ngôn ngữ: eng
• Ký hiệu phân loại: 343.076—343.078 Military, defense, public property, public finance, tax, commerce (trade), industrial law
• Thông tin xuất bản: United States : ACS chemical neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 191649

Tóm tắt

Human histidine triad nucleotide-binding protein 1 (HINT1) has recently become a protein of interest due to its involvement in several CNS processes, including neuroplasticity and the development of several neuropsychiatric disorders. Crucially, HINT1 behaves as a mediator for cross-regulation of the mu-opioid receptor (MOR) and