Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes.

• Tác giả: Michael Ailion, Yousun An, Cedric Asensio, Jerome Cattin-Ortolá, Alexis Diaz-Vegas, Mark Germanos, Melkam Alamerew Kebede, Mark Larance, Thomas Loudovaris, Drew Masler, Sheyda Naghiloo, Elise J Needham, Kitty Sun, Matthew Taper, Helen Thomas, Peter Thorn, Jason Tong, A Gabrielle van der Kraan, Helen von Blume, Amy Wilson, Belinda Yau, Cara Yeoman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.1135 Sources
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 191664

Tóm tắt

In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca