Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.

• Tác giả: Ikuro Abe, Lide Cha, Wei-Chen Chang, Yisong Guo, Xiaojun Li, Charalambos Michael, Yasushi Ogasawara, Jared C Paris, Richiro Ushimaru, Yu-Cong Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.13637 Aerospace engineering
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 192243

Tóm tắt

 Despite the diversity of reactions catalyzed by mononuclear iron and 2-oxoglutarate-dependent enzymes, the factors that lead to diverse reaction outcomes beyond canonical hydroxylation remain elusive. Cyclopropanation reactions are of particular interest not only due to the prevalence of cyclopropane moieties in pharmaceuticals but also due to the chemistry that allows cyclopropanation to outcompete oxygen rebound. HrmJ is one such cyclopropanase from the biosynthetic pathway of hormaomycin
  however, a homologue is herein discovered that instead catalyzes