Tetrahydrocurcumin exhibits neuroprotective effects by inhibiting neuron ferroptosis via activity of iPLA2β/p38 MAPK phosphorylation in rat TBI model.

• Tác giả: Yonghong Bi, Pengyu Duan, Weiyu Feng, Guanghui He, Zhehao Jin, Xiaoyan Li, Lan Luo, Bing Zhang, Xiaoqian Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.7 Military installations
• Thông tin xuất bản: England : Free radical research , 2025
• Bộ sưu tập: NCBI
• ID: 194672

Tóm tắt

Ferroptosis characterized by iron-dependent lipid peroxidation induced by traumatic brain injury (TBI) is an important factor that aggravates diseases. Studies have shown that tetrahydrocurcumin (THC) has neuroprotective effects in brain injury. However, whether THC inhibits neurocyte ferroptosis after TBI and its mechanism remains unclear. To investigate this, a weight-drop model in rats and H