We propose a deep learning approach to probabilistic forecasting of macroeconomic and financial time series. Being able to learn complex patterns from a data rich environment, our approach is useful for a decision making that depends on uncertainty of large number of economic outcomes. Specifically, it is informative to agents facing asymmetric dependence of their loss on outcomes from possibly non-Gaussian and non-linear variables. We show the usefulness of the proposed approach on the two distinct datasets where a machine learns the pattern from data. First, we construct macroeconomic fan charts that reflect information from high-dimensional data set. Second, we illustrate gains in prediction of stock return distributions which are heavy tailed, asymmetric and suffer from low signal-to-noise ratio.