A conceptual framework for modeling a latching mechanism for cell cycle regulation.

• Tác giả: Punit Gandhi, Yangyang Wang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mathematical biosciences , 2025
• Bộ sưu tập: NCBI
• ID: 195192

Tóm tắt

Two identical van der Pol oscillators with mutual inhibition are considered as a conceptual framework for modeling a latching mechanism for cell cycle regulation. In particular, the oscillators are biased to a latched state in which there is a globally attracting steady-state equilibrium without coupling. The inhibitory coupling induces stable alternating large-amplitude oscillations that model the normal cell cycle. A homoclinic bifurcation within the model is found to be responsible for the transition from normal cell cycling to endocycles in which only one of the two oscillators undergoes large-amplitude oscillations.