Perceptual responses may influence how much pleasure or displeasure an individual experiences during or following resistance training (RT). Resistance-trained males (n = 12) and females (n = 6) completed an 8-week intervention involving two RT sessions per week. The lower limbs of each participant were randomised to perform the leg press and leg extension exercises either to (i) momentary muscular failure (FAIL) or (ii) a perceived 2-RIR and 1-RIR, respectively, for the entire intervention. In weeks one, four, and eight, post-set ratings of perceived discomfort (RPD), and post-session ratings of perceived exertion (RPE) and general feelings via feeling scale (FS) were measured. Data were analysed with Bayesian mixed-effect models. When averaged over all time points measured, results showed slightly greater RPD for FAIL [5.1 (HDI: 4.2-6.0)
pd = 100%] versus RIR [4.1 (HDI: 3.2-5.1)
pd = 100%], greater RPE for FAIL [5.4 (HDI: 4.6-6.3)
pd = 100%] versus RIR [4.3 (HDI: 3.5-5.1)
pd = 100%], and more positive general feelings for RIR [1.2 (HDI: 0.7-1.8)
pd = 100%] versus FAIL [0.3 (HDI: -0.3 to 0.8)
pd = 86%]. Overall, assessing perceptual responses may help inform RIR prescription to promote desired outcomes whilst limiting negative feelings that may compromise long-term adherence.