BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder marked by motor impairments such as stiffness, involuntary shaking, and slowed movement. In addition, PD patients frequently experience nonmotor symptoms, especially depression. This study uses a mixed-methods scientometric analysis to review global research trends and advancements in PD and depression. This analysis is vital for clinicians, researchers, and policymakers, identifying knowledge gaps and directing future research efforts. METHODS: We conducted a comprehensive literature review on PD and depression using the Web of Science database from 2004 to 2023, facilitated by CiteSpace 6.1.R6. Our analysis examined collaborations among authors, institutions, countries, and keywords, incorporating insights from RCTs and qualitative studies. We calculated effect sizes and confidence intervals with precision. Ethical approval was not required as the study used publicly available data without personal information. RESULTS: Our analysis included 3048 research papers and 915 reviews, involving 17,927 authors and 12,466 institutions. The United States and the University of Toronto led in publications. Studies revealed significant effect sizes with narrow confidence intervals, particularly on the prevalence and impact of depression in PD patients. High-frequency keywords included "Parkinson's disease," "depression," "quality of life," "non-motor symptom," and "dementia." Visual mapping identified critical research nodes and future directions. CONCLUSION: Over the past 2 decades, research on the PD-depression link has accelerated. Our analysis highlights prevailing trends and critical areas, providing evidence-based recommendations for therapeutic strategies. This study offers valuable insights for clinicians and researchers, emphasizing future research priorities to improve patient outcomes.