Did migrants make Paris a Mecca for the arts and Vienna a beacon of classical music? Or was their rise a pure consequence of local actors? Here, we use data on more than 22,000 historical individuals born between the years 1000 and 2000 to estimate the contribution of famous immigrants, emigrants, and locals to the knowledge specializations of European regions. We find that the probability that a region develops or keeps specialization in an activity (based on the birth of famous physicists, painters, etc.) grows with both, the presence of immigrants with knowledge on that activity and immigrants with knowledge in related activities. In contrast, we do not find robust evidence that the presence of locals with related knowledge explains entries and/or exits. We address some endogeneity concerns using fixed-effects models considering any location-period-activity specific factors (e.g. the presence of a new university attracting scientists).