The prognostic value of NT-proBNP in 28-day mortality and post-discharge survival in pneumonia: a retrospective cohort study from Taiwan.

• Tác giả: Chun-You Chen, Jing-En Dai, Pei-Ni Hsieh, Ke-Shiuan Ju, Chih-Hsin Lee, Wen-Chen Lee, Hsien-Chun Lin, Van-Dong Nguyen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 371.26 Examinations and tests; academic prognosis and placement
• Thông tin xuất bản: England : Expert review of respiratory medicine , 2025
• Bộ sưu tập: NCBI
• ID: 196163

Tóm tắt

 BACKGROUND: NT-proBNP, traditionally used to assess heart failure, is increasingly recognized for its prognostic value in other diseases. This study evaluates its value in pneumonia. RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study of adult patients hospitalized for pneumonia at Wan Fang Hospital (2017-2021) to investigate whether elevated NT-proBNP levels predicted poorer outcomes. Logistic regression identified risk factors for 28-day mortality, while the Cox regression model identified predictors of post-discharge survival. RESULTS: Among 2,805 patients (79.6 ± 13.4 years, female 45%), the 28-day mortality rate was 18.2%, and the median post-discharge follow-up time was 359 days. Moderately (increased but <
  10000 pg/mL) and severely (>
 10000 pg/mL) elevated NT-proBNP levels had higher 28-day mortality compared to normal NT-proBNP
  adjusted odds ratios: 2.24 (1.34-3.75, CONCLUSIONS: Elevated NT-proBNP levels predict higher 28-day mortality and shorter survival time in patients with pneumonia across most subpopulations. This marker holds potential as a prognostic biomarker for pneumonia, especially in high-risk patients.