Chirality is a fundamental property widely observed in nature, arising in objects without a proper rotation axis, therefore existing as forms with distinct handedness. This characteristic can profoundly impact the properties of materials and can enable new functionality, especially for spin-optoelectronics. Chirality enables asymmetric light and spin interactions in materials, with widespread potential applications ranging from energy-efficient displays, holography, imaging, and spin-selective and enantio-selective chemistry to quantum information technologies. This Review focuses on the emerging material class of solution-processable chiral semiconductors, a broad material class comprising organic, inorganic and hybrid materials. These exciting materials offer the opportunity to design desirable light-matter interactions based on symmetry rules, potentially enabling the simultaneous control of light, charge and spin. We briefly discuss the various types of solution-processible chiral semiconductors, including small molecules, polymers, supramolecular self-assemblies and halide perovskites. We then examine the interplay between chirality and spin in these materials, the various mechanisms of chiral light-matter interactions, and techniques utilized to characterize them. We conclude with current and future applications of chiral semiconductors that take advantage of their chiral light-matter interactions.