Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2

• Tác giả: Ivi Theodosia Antoniadou, Salvatore Chiantia, David Fedida, Agni Gavriilidou, F Brent Johnson, Antonios Kolocouris, Daniel C Kwan, Cato Mestdagh, Lieve Naesens, Annett Petrich, Michail Rallis, Francesc X Sureda, Ian Tietjen, Christina Tzitzoglaki, Roland Zell
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: Netherlands : Antiviral research , 2025
• Bộ sưu tập: NCBI
• ID: 197138

Tóm tắt

To better manage seasonal and pandemic influenza infections, new drugs are needed with enhanced activity against amantadine- and rimantadine-resistant influenza A virus (IAV) strains containing the S31N variant of the viral M2 ion channel (M2