The ability to manage more complex coronary disease has evolved with the development of new technologies, techniques, and practitioner experience. The increasing technical difficulty of interventional procedures is known to be associated with an increased risk of complications. This can include coronary perforation, coronary dissection, coronary thrombosis, and aortic valve dysfunction. Permanent aortic valve damage caused by guide catheter, wire instrumentation or stent migration is a rare occurrence. We report the case of a woman in her 50s who developed acute severe aortic regurgitation requiring aortic valve replacement post-percutaneous coronary intervention.