Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy.

• Tác giả: Yingyu Cai, Ran Hu, Fan Li, Sen Tong, Tong Wang, Gareth R Williams, Junzi Wu, Jianxiang Xu, Yanyan Zhang, Yilu Zheng, Li-Min Zhu
• Ngôn ngữ: eng
• Thông tin xuất bản: New Zealand : International journal of nanomedicine , 2025
• Bộ sưu tập: NCBI
• ID: 197505

Tóm tắt

BACKGROUND: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy. METHODS: Here, we report a "nanobomb" that explosively increases Ca content within cells. It can selectively release Ca RESULTS: Under the slightly acidic conditions of the TME, the PAA shell (first lock) breaks down first exposing CaO DISCUSSION: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. The mode triggers apoptosis leading to ICD of tumor cells. The material induces cycle blockade during treatment to inhibit cell proliferation. Robust in vitro and in vivo data demonstrate the efficacy of this approach and CaO