Hewei Jiangni granule alleviates visceral hypersensitivity of non-erosive reflux diseasestromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway.

• Tác giả: Xie Chune, Kou Fushun, L I Junxiang, Shi Lei, Zhang Liming, L I Xiaohong, Zhang Xiaosi, Dai Yi, Cheng Yuan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: China : Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan , 2025
• Bộ sưu tập: NCBI
• ID: 197841

Tóm tắt

OBJECTIVE: To explore if Hewei Jiangni granule (, HWJNG) could regulate esophageal hypersensitivity via stromal interaction molecule 1 (STIM1)/transient receptor potential vanilloid subfamily member 1 (TRPV1) pathway. METHODS: Qualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography. RESULTS: HWJNG significantly suppressed intercellular space widening, injury of mitochondrial, MCs degranulation, mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice. HWJNG inhibited expression of visceral hypersensitivity-related gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells, and expression of the STIM1, TRPV1 and related neurotransmitters in DRG and DRG cells. STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca CONCLUSION: HWJNG suppressed intercellular space widening in NERD mice, stabilized MCs and restored neuronal hyperexcitability by regulating visceral hypersensitivity