PURPOSE: To explore the association of the Systemic Inflammatory Response Index (SIRI) and Systemic Inflammatory Immunity Index (SII) with extended-spectrum β-lactamase (ESBL)-producing METHODS: A total of 425 patients with RESULTS: SIRI and SII levels in the ESBL-producing group were significantly higher than those in the non-ESBL-producing group. Logistic regression analysis showed that the odds ratios for SIRI and SII were 1.092 and 1.158, respectively, with 95% confidence intervals of 1.001-1.115 and 1.015-1.204, respectively. The critical values for predicting ESBL-producing CONCLUSION: SIRI and SII are significantly associated with the risk of ESBL-producing