OBJECTIVE: This study aims to investigate the current status of physical exercise behavior, academic engagement, and self-efficacy among non-physical education college students. Additionally, it sought to analyze the relationships between these factors in order to explore the potential impact of physical exercise on learning and self-efficacy. METHODS: To examine the current status and relationships between physical exercise behavior, academic engagement, and self-efficacy, this study used the Physical Activity Rating Scale (PARS-3), the Utrecht Work Engagement Scale (UWES), and the General Self-Efficacy Scale (GESE) as research tools. A stratified random sampling method was employed, and non-physical education college students were selected as participants. A total of 1,596 valid questionnaires were analyzed. The data were processed using SPSS 26.0, AMOS 26.0, and Excel 2010, with statistical analyses including one-way ANOVA, correlation analysis, regression analysis, and mediation effect testing. RESULTS: Physical exercise behavior among non-physical education students showed significant positive correlations with academic engagement ( CONCLUSION: Physical exercise behavior significantly predicts academic engagement, and a positive predictive relationship exists between physical exercise and self-efficacy. Additionally, self-efficacy plays a significant role in predicting academic engagement. Self-efficacy partially mediates the relationship between physical exercise behavior and academic engagement.