INTRODUCTION: Classification of patients with METHODS: We conducted a post hoc secondary analysis of the CAMERA2 trial, which enrolled hospitalized adult patients with methicillin-resistant RESULTS: A total of 345 patients were included in this analysis, of whom 63 (18.3%) died within 90 days. Fever (body temperature ≥38.0 °C) was associated with increased odds of 90-day mortality from day 4 and onwards. Fever later in the illness course was associated with higher adjusted odds of mortality (8.78
95% confidence interval, 2.78-27.7 on day 7 vs adjusted odds ratio 3.70
95% CI, 1.58-8.67 on day 4). In contrast, CRP and abnormal WBC count did not demonstrate a consistent or temporal association with mortality. CONCLUSIONS: Persistent fever after 72 hours is associated with increased mortality in patients with methicillin-resistant