Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis.

• Tác giả: Momina Ahmed, Vincent Archambault, Éric Bonneil, Mohammed Bourouh, Victoria Ginestet, Laia Jordana, Jingjing Li, Cristina Mirela Pascariu, T Martin Schmeing, Pierre Thibault, Xinyue Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 303.623 Riots
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 197999

Tóm tắt

In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 (also known as LEM4 in humans) which interacts with PP2A and promotes the function of the Barrier-to-Autointegration Factor (BAF). Upon dephosphorylation, BAF dimers cross-bridge chromosomes and bind lamins and transmembrane proteins of the reassembling nuclear envelope. How Ankle2 functions in mitosis is incompletely understood. Using a combination of approaches in