ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep.

• Tác giả: Caitlin M Carroll, Nicholas J Constantino, Lance A Johnson, Shannon L Macauley, Josh M Morganti, Erik S Musiek, Marcus E Raichle, Kai Saito, Patrick W Sheehan, J Andy Snipes, Patrick G Sullivan, Hemendra J Vekaria, Holden C Williams, Carla M Yuede
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 198027

Tóm tắt

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required for sleep. ATP-sensitive potassium (K